University of Wisconsin–Madison

Tag: health & medicine

Study reveals new options for people with PKU

For people with the genetic condition known as phenylketonuria (PKU), diet is a constant struggle. They can eat virtually no protein, and instead get their daily dose of this key macronutrient by drinking a bitter-tasting formula of amino acids. Yet drink it they must; deviating from this strict dietary regimen puts them at risk of developing permanent neurological damage.

Clinical trial uses bat saliva enzyme for stroke treatment

Vampires aren’t usually cast in the role of saviors, but stroke experts are hoping a blood thinner that mimics a chemical in vampire saliva will help save brain cells in stroke patients. The School of Medicine and Public Health is one of several centers worldwide currently enrolling patients in a large new clinical trial of desmoteplase, a drug based on an enzyme in vampire bat saliva.

Patient-derived induced stem cells retain disease traits

When neurons started dying in Clive Svendsen’s lab dishes, he couldn’t have been more pleased. The dying cells – the same type lost in patients with the devastating neurological disease spinal muscular atrophy – confirmed that the University of Wisconsin-Madison stem cell biologist had recreated the hallmarks of a genetic disorder in the lab, using stem cells derived from a patient.

Genetic change extends mouse life, points to possible treatment for ALS

There are many ways to die, but amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, must be one of the worst. By the time a patient notices muscle weakness, the neurons that control the muscles have already begun dying, in an untreatable process that brings death within two to five years.