The blood-brain barrier -- the filter that governs what can and cannot come into contact with the mammalian brain -- is a marvel of nature. It effectively separates circulating blood from the fluid that bathes the brain, and it keeps out bacteria, viruses and other agents that could damage it.
Breast-cancer researchers at the University of Wisconsin–Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells.
Scientific leaders in the use of stem cells to solve scientific and medical problems will gather Wednesday, April 11 at the BioPharmaceutical Technology Center Institute in Fitchburg, just south of Madison.
Huntington's disease, the debilitating congenital neurological disorder that progressively robs patients of muscle coordination and cognitive ability, is a condition without effective treatment, a slow death sentence.
For the first time, scientists at the University of Wisconsin–Madison have made early retina structures containing proliferating neuroretinal progenitor cells using induced pluripotent stem (iPS) cells derived from human blood.
UW Law Professor R. Alta Charo was senior policy adviser to the commissioner at the Food and Drug Administration from August 2009 until June 2011. Now back on campus, Charo spoke reflects on her time with the FDA.
The Wisconsin Institutes for Discovery, the innovative 330,000-sqaure-foot public-private facility that opened just more than a year ago on the UW–Madison campus, has been named the 2012 Laboratory of the Year.
Using lab-grown human neurons, researchers from the University of Wisconsin–Madison have devised an effective assay for detecting botulinum neurotoxin, the agent widely used to cosmetically smooth the wrinkles of age and, increasingly, for an array of medical disorders ranging from muscle spasticity to loss of bladder control.
Among the many hurdles to be cleared before human embryonic stem cells can achieve their therapeutic potential is determining whether or not transplanted cells can functionally integrate into target organs or tissues.
Ever since human induced pluripotent stem cells were first derived in 2007, scientists have wondered whether they were functionally equivalent to embryonic stem cells, which are sourced in early stage embryos.
Eighteen students participating in the inaugural Global Wisconsin Idea Program -- a unique pairing of American and Chinese teenagers -- will join a Chinese university dean this week to learn more about the science of stem cells during a hands-on workshop hosted by the Morgridge Institute for Research.
Soon, some treatments for blinding eye diseases might be developed and tested using retina-like tissues produced from the patient's own skin, thanks to a series of discoveries reported by a team of University of Wisconsin–Madison stem cell researchers.
A research team at the University of Wisconsin School of Medicine and Public Health is the first to use heart cells derived from stem cells to specifically study certain genetic mechanisms of heart diseases.
Scientists from the Morgridge Institute for Research, the University of Wisconsin–Madison, the University of California and the WiCell Research Institute moved gene therapy one step closer to clinical reality by determining that the process of correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells.
In recognition of his pioneering work in isolating human stem cells and the promise they hold for the future of medicine, Wisconsin researcher James Thomson has been named a co-recipient of the 11th annual Albany Medical Center Prize in Medicine and Biomedical Research.