Tag Pharmacy
Common chemotherapy drugs don’t work like doctors thought, with big implications for drug discovery
Findings reveal the likely reason why certain chemotherapies are effective for many patients. Importantly, they also help explain why attempts to find new chemo drugs based solely on stopping cellular division have been so disappointing.
New technique, effective in mice, could help advance the use of probiotics
Researchers in the School of Pharmacy, led by Quanyin Hu, have developed a system that can keep probiotic bacteria alive in the lower intestine long enough to help treat or prevent colitis in a mouse model of the disease.
New chemistry makes ‘magic’ drug improvements easier
Drug developers could use the technique to test whether a drug candidate might be improved with a new methyl group, potentially saving otherwise promising drugs from the trash heap.
New method targets disease-causing proteins for destruction
The technology, developed by UW–Madison Professor Weiping Tang and colleagues in the School of Pharmacy, could produce entirely new kinds of drugs.
Pharmacy students meet urgent need for vaccinators in Wisconsin
“It’s a win-win,” says pharmacy student Maggie Hoernke. “We get practice educating patients and administering the vaccine, and we also get to help out the public.
Patients taking opioids produce antibodies that may hinder anti-opioid vaccine
The findings add to a growing understanding of how the immune system can recognize drugs and influence their effects in the body, which may ultimately support the production and delivery of a vaccine that reduces the harm of opioid abuse.
School of Pharmacy team produces hand sanitizer for UW Health
The school's Zeeh Pharmaceutical Experiment Station started production on March 20 and, in less than a week, provided more than 100 gallons of vitally important sanitizer.
Cheap nanoparticles stimulate immune response to cancer in the lab
If they are shown to work as well in the body as they do in pharmacy Professor Seungpyo Hong's lab, the nanoparticles might provide an effective and more affordable way to fight cancer.
New director of UW CIPE focuses on health-care collaboration
He says CIPE’s focus on team-based learning and practice will provide UW–Madison health sciences students purposefully-designed interprofessional learning and socialization, both of which will better prepare them for team-based practice.
Relieving two headaches with one process
A team of UW–Madison researchers has been awarded a patent for a method to synthesize acetaminophen — the active ingredient in Tylenol — from a natural compound derived from plant material.
Long delays prescribing new antibiotics hinder market for needed drugs
A survey of 132 hospitals found that the delays could reduce the likelihood that drug companies will develop new antibiotics essential for treating diseases.
Antibiotic resistance across Wisconsin revealed by new maps
Researchers drew inspiration from easy-to-read weather maps and consulted with doctors to provide guidance at a glance of the likelihood a pathogen will respond to a particular drug in different parts of the state.
WARF bets big on new squad of drug hunters
“We are building a preclinical drug discovery organization,” says WARF Therapeutics Director Jon Young, who has worked in drug development at Merck Research Laboratories, Regulus Therapeutics and Celgene.
Program empowers communities to overpower diabetes
A UW–Madison program aims to give African Americans in Milwaukee strategies to maintain healthy lifestyles that will help prevent and/or manage Type 2 diabetes.
Gene-editing tool now being used to develop better antibiotics
Jason Peters and colleagues have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ones.
Inflammation biomarker in blood may help predict effectiveness of depression drugs
A simple blood test could help doctors understand what medication might work best for patients at the start of their treatment, according to new UW–Madison research.
Nanoparticles improve tumor treatment in mice
In mouse models of human lung cancer, the improved drug inhibited tumor growth more effectively than the standard drug. “Ultimately, our goal is to get this into human beings,” says pharmacy professor Glen Kwon.
Cell therapy is the future, and Wisconsin is the place, UW–Madison expert tells Technology Council
UW–Madison has doctors willing to guide the studies that will make or break cell therapy companies. “If you are a clinician, you need a pioneer spirit to do something that has never been done before,” Jacques Galipeau says, “and there are already many like that here.”
Searching the sea, and bacterial battles, for new antibiotics
Researchers in pharmacy and bacteriology say their discovery would not have been possible without a cross-college collaboration going back nearly a decade.
Improved capture of cancer cells in blood could help track disease
By forcing cancer cells to slow down and developing stronger molecular traps specific to circulating tumor cells, researchers were able to identify large numbers of the cells in cancer patients undergoing radiation therapy.